KCTD15

Chr 19q13.11

potassium channel tetramerization domain containing 15

Aliases:: MGC25497
MANE:: ENST00000683859.1

OMIM: 615240 ↗NCBI: 79047 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KCTD15 · Q96SI1

v62025-08-01

Predicted Aligned Error matrix for KCTD15 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.2/ 100

Confident

283 residues

Confidence breakdown

Very high(≥ 90)57%
Confident(70–90)16%
Low(50–70)16%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Paediatric disorders - additional genes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Abnormality of the skeletal system
0.49
facial morphology
0.34
smoking behavior
0.31
type 2 diabetes mellitus
0.28
cervical carcinoma
0.25
skin aging
0.19
frontonasal dysplasia
0.19
tooth disorder
0.16
response to radiation
0.15
protozoa infectious disease
0.15

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

BTB/POZ domain-containing protein KCTD15

During embryonic development, it is involved in neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain (PubMed:23382213)