KDM4B

Chr 19p13.3

lysine demethylase 4B

Aliases:: KIAA0876, TDRD14B
MANE:: ENST00000159111.9

OMIM: 609765 ↗NCBI: 23030 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KDM4B · O94953

v62025-08-01

Predicted Aligned Error matrix for KDM4B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.5/ 100

Low

1,096 residues

Confidence breakdown

Very high(≥ 90)34%
Confident(70–90)27%
Low(50–70)6%
Very low(< 50)33%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

intellectual developmental disorder, autosomal dominant 65
0.72
hereditary disease
0.50
hypertensive disorder
0.47
essential hypertension
0.42
complex neurodevelopmental disorder
0.37
Increased blood pressure
0.36
atrial fibrillation
0.35
gout
0.35
Neurodevelopmental delay
0.33
insomnia
0.32

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Lysine-specific demethylase 4B

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS)