KIF12

Chr 9q32

kinesin family member 12

MANE:: ENST00000640217.2

OMIM: 611278 ↗NCBI: 113220 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

KIF12 · Q96FN5

v62025-08-01

Predicted Aligned Error matrix for KIF12 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

70.2/ 100

Confident

646 residues

Confidence breakdown

Very high(≥ 90)29%
Confident(70–90)30%
Low(50–70)13%
Very low(< 50)28%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cholestasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cholestasis, progressive familial intrahepatic, 8
0.69
cholestasis
0.38
pathological myopia
0.34
Alzheimer disease
0.29
neurodegenerative disease
0.29
multiple sclerosis
0.29
lysosomal storage disease
0.29
Parkinson disease
0.29
urolithiasis
0.29
alcohol drinking
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Kinesin-like protein KIF12

Involved in the negative regulation of fatty acid biosynthesis, probably acting as an adapter that allows ubiquitination of acetyl-CoA carboxylase 1 (ACACA) by E3 ubiquitin-protein ligase COP1, and promotes ACACA degradation (PubMed:39920308). The adapter function requires the C-terminal proline-rich domain and may be apart from the kinesin motor activity (Probable)