KIF14

Chr 1q32.1

kinesin family member 14

Aliases:: KIAA0042
MANE:: ENST00000367350.5

OMIM: 611279 ↗NCBI: 9928 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

KIF14 · Q15058

v62025-08-01

Predicted Aligned Error matrix for KIF14 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

65.3/ 100

Low

1,648 residues

Confidence breakdown

Very high(≥ 90)16%
Confident(70–90)40%
Low(50–70)11%
Very low(< 50)33%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Renal ciliopathies
BIALLELIC, autosomal or pseudoautosomal
Ductal plate malformation
BIALLELIC, autosomal or pseudoautosomal
Familial Neural Tube Defects
BIALLELIC, autosomal or pseudoautosomal
Neurological ciliopathies
BIALLELIC, autosomal or pseudoautosomal

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Disease associations (Open Targets)

microcephaly 20, primary, autosomal recessive
0.72
lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome
0.70
autosomal recessive primary microcephaly
0.67
neurodegenerative disease
0.55
Joubert syndrome and related disorders
0.40
hereditary disease
0.19
hepatocellular carcinoma
0.11
colorectal carcinoma
0.11
lysosomal storage disease
0.11
neoplasm
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Kinesin-like protein KIF14

Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:16648480, PubMed:24784001). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302)