KIF21B

Chr 1q32.1

kinesin family member 21B

Aliases:: DKFZP434J212, KIAA0449
MANE:: ENST00000461742.7

OMIM: 608322 ↗NCBI: 23046 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KIF21B · O75037

v62025-08-01

Predicted Aligned Error matrix for KIF21B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.6/ 100

Low

1,637 residues

Confidence breakdown

Very high(≥ 90)25%
Confident(70–90)37%
Low(50–70)12%
Very low(< 50)26%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

microcephaly
0.42
Global developmental delay
0.42
Intellectual disability
0.42
Abnormal brain morphology
0.42
neurodevelopmental disorder
0.37
ulcerative colitis
0.29
Cachexia
0.29
autoimmune disease
0.27
ankylosing spondylitis
0.27
brain aneurysm
0.25

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Kinesin-like protein KIF21B

Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface