KIF22

Chr 16p11.2

kinesin family member 22

Aliases:: Kid, OBP-1, OBP-2
MANE:: ENST00000160827.9

OMIM: 603213 ↗NCBI: 3835 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

KIF22 · Q14807

v62025-08-01

Predicted Aligned Error matrix for KIF22 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.9/ 100

Confident

665 residues

Confidence breakdown

Very high(≥ 90)38%
Confident(70–90)28%
Low(50–70)10%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Skeletal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Clefting
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Osteogenesis imperfecta

Disease associations (Open Targets)

spondyloepimetaphyseal dysplasia with multiple dislocations
0.77
hereditary disease
0.42
spondyloepimetaphyseal dysplasia with joint laxity
0.37
skeletal dysplasia
0.12
neoplasm
0.08
orchitis
0.08
epididymitis
0.08
gastric cancer
0.08
melanoma
0.08
urinary bladder cancer
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Kinesin-like protein KIF22

Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205)