KIF23

Chr 15q23

kinesin family member 23

Aliases:: MKLP1, MKLP-1
MANE:: ENST00000679126.1

OMIM: 605064 ↗NCBI: 9493 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KIF23 · Q02241

v62025-08-01

Predicted Aligned Error matrix for KIF23 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.8/ 100

Confident

960 residues

Confidence breakdown

Very high(≥ 90)44%
Confident(70–90)23%
Low(50–70)7%
Very low(< 50)27%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cytopenias and congenital anaemias
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Rare anaemia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

congenital dyserythropoietic anemia type 3
0.73
Congenital dyserythropoietic anemia type III
0.73
hypertensive disorder
0.42
neurodegenerative disease
0.37
response to xenobiotic stimulus
0.28
microcephaly
0.27
cardiovascular disorder
0.15
essential hypertension
0.15
hepatocellular carcinoma
0.12
B-cell chronic lymphocytic leukemia
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Kinesin-like protein KIF23

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro