KIF24

Chr 9p13.3

kinesin family member 24

Aliases:: bA571F15.4, FLJ10933, FLJ43884
MANE:: ENST00000402558.7

OMIM: 613747 ↗NCBI: 347240 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KIF24 · Q5T7B8

v62025-08-01

Predicted Aligned Error matrix for KIF24 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

51.4/ 100

Low

1,368 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)15%
Low(50–70)4%
Very low(< 50)63%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

skeletal dysplasia
0.46
asphyxiating thoracic dystrophy 3
0.33
adolescent idiopathic scoliosis
0.28
osteoarthritis, hip
0.24
placenta praevia
0.24
total joint arthroplasty
0.24
placental retention
0.24
osteoarthritis, knee
0.24
neurodegenerative disease
0.21
peripheral neuropathy
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Kinesin-like protein KIF24

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation (PubMed:21620453). Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (PubMed:26290419). Plays an important role in recruiting MPHOSPH9, a negative regulator of cilia formation to the distal end of mother centriole (PubMed:30375385)