KIF26A

Chr 14q32.33

kinesin family member 26A

Aliases:: KIAA1236, DKFZP434N178
MANE:: ENST00000423312.7

OMIM: 613231 ↗NCBI: 26153 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

KIF26A · Q9ULI4

v62025-08-01

Predicted Aligned Error matrix for KIF26A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

47.1/ 100

Very low

1,882 residues

Confidence breakdown

Very high(≥ 90)11%
Confident(70–90)12%
Low(50–70)6%
Very low(< 50)72%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Hydrocephalus
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Malformations of cortical development
BIALLELIC, autosomal or pseudoautosomal
Paediatric pseudo-obstruction syndrome
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cortical dysplasia, complex, with other brain malformations 11
0.69
smoking initiation
0.38
smoking cessation
0.38
complex cortical dysplasia with other brain malformations
0.37
diabetes mellitus
0.36
stricture
0.32
nicotine dependence
0.31
mental disorder
0.30
type 2 diabetes mellitus
0.29
male reproductive organ cancer
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Kinesin-like protein KIF26A

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling (By similarity). Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity). Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons (PubMed:36228617)