KIF3B

Chr 20q11.21

kinesin family member 3B

Aliases:: KIAA0359, FLA8, KLP-11
MANE:: ENST00000375712.4

OMIM: 603754 ↗NCBI: 9371 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KIF3B · O15066

v62025-08-01

Predicted Aligned Error matrix for KIF3B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.5/ 100

Confident

747 residues

Confidence breakdown

Very high(≥ 90)28%
Confident(70–90)44%
Low(50–70)16%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Ophthalmological ciliopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Retinal disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

retinitis pigmentosa 89
0.52
neurodegenerative disease
0.37
oligospermia
0.33
alcohol drinking
0.28
Abnormality of the skeletal system
0.26
respiratory failure
0.25
asthma
0.24
Alzheimer disease
0.24
Hepatic fibrosis
0.23
postaxial polydactyly
0.23

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Kinesin-like protein KIF3B

Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity). Plays a role in cilia formation (PubMed:32386558). Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed:32386558). Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (By similarity)