KLF2

Chr 19p13.11

KLF transcription factor 2

Aliases:: LKLF
MANE:: ENST00000248071.6

OMIM: 602016 ↗NCBI: 10365 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

KLF2 · Q9Y5W3

v62025-08-01

Predicted Aligned Error matrix for KLF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

56.8/ 100

Low

355 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)26%
Low(50–70)30%
Very low(< 50)44%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
Unknown

Disease associations (Open Targets)

neurodegenerative disease
0.54
plasma cell myeloma
0.45
Varicose veins
0.44
coronary artery disorder
0.39
systemic lupus erythematosus
0.38
lymphatic system disorder
0.35
vein disorder
0.35
brain cancer
0.30
immunodeficiency disease
0.26
asthma
0.25

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Krueppel-like factor 2

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758)