KLF7

Chr 2q33.3

KLF transcription factor 7

Aliases:: UKLF
MANE:: ENST00000309446.11

OMIM: 604865 ↗NCBI: 8609 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KLF7 · O75840

v62025-08-01

Predicted Aligned Error matrix for KLF7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

53.4/ 100

Low

302 residues

Confidence breakdown

Very high(≥ 90)7%
Confident(70–90)25%
Low(50–70)16%
Very low(< 50)53%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

neurodegenerative disease
0.53
hereditary disease
0.47
prostate carcinoma
0.47
neurodevelopmental disorder
0.45
hearing loss disorder
0.45
Intellectual disability
0.45
major depressive disorder
0.43
presbycusis
0.39
lysosomal storage disease
0.37
insomnia
0.36

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Krueppel-like factor 7

Transcriptional factor (PubMed:16339272, PubMed:9774444). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Also acts as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272)