KLK4

Chr 19q13.41

kallikrein related peptidase 4

Aliases:: EMSP, EMSP1, PSTS, KLK-L1
MANE:: ENST00000324041.6

OMIM: 603767 ↗NCBI: 9622 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

KLK4 · Q9Y5K2

v62025-08-01

Predicted Aligned Error matrix for KLK4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.1/ 100

Very high

254 residues

Confidence breakdown

Very high(≥ 90)83%
Confident(70–90)5%
Low(50–70)2%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Amelogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Hypomaturation amelogenesis imperfecta
0.67
amelogenesis imperfecta
0.52
Graves disease
0.35
stroke disorder
0.20
hereditary disease
0.19
alcohol drinking
0.19
male infertility
0.11
prostate carcinoma
0.11
prostate cancer
0.11
Familial prostate cancer
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Kallikrein-4

Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity)