KLKB1

Chr 4q35.2

kallikrein B1

MANE:: ENST00000264690.11

OMIM: 229000 ↗NCBI: 3818 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KLKB1 · P03952

v62025-08-01

Predicted Aligned Error matrix for KLKB1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.9/ 100

Confident

638 residues

Confidence breakdown

Very high(≥ 90)69%
Confident(70–90)21%
Low(50–70)3%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BIALLELIC, autosomal or pseudoautosomal
Inherited bleeding disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

inherited prekallikrein deficiency
0.70
prekallikrein deficiency
0.67
hereditary angioedema
0.59
Congenital prekallikrein deficiency
0.56
venous thromboembolism
0.50
blood coagulation disease
0.49
angioedema
0.45
serum lipopolysaccharide activity
0.42
hemorrhage
0.39
heart disorder
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Plasma kallikrein

Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin