KRT16

Chr 17q21.2

keratin 16

Aliases:: NEPPK
MANE:: ENST00000301653.9

OMIM: 148067 ↗NCBI: 3868 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KRT16 · P08779

v62025-08-01

Predicted Aligned Error matrix for KRT16 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

71.6/ 100

Confident

473 residues

Confidence breakdown

Very high(≥ 90)50%
Confident(70–90)10%
Low(50–70)5%
Very low(< 50)36%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ichthyosis and erythrokeratoderma
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Palmoplantar keratoderma and erythrokeratodermas
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

pachyonychia congenita
0.78
palmoplantar keratoderma, nonepidermolytic, focal 1
0.67
pachyonychia congenita 1
0.66
Non-epidermolytic palmoplantar keratoderma
0.56
focal palmoplantar keratoderma
0.46
hereditary disease
0.19
palmoplantar keratoderma, epidermolytic
0.13
Localized epidermolytic hyperkeratosis
0.12
psoriasis
0.11
neoplasm
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Keratin, type I cytoskeletal 16

Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance