KRT25

Chr 17q21.2

keratin 25

MANE:: ENST00000312150.5

OMIM: 616646 ↗NCBI: 147183 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KRT25 · Q7Z3Z0

v62025-08-01

Predicted Aligned Error matrix for KRT25 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.1/ 100

Confident

450 residues

Confidence breakdown

Very high(≥ 90)51%
Confident(70–90)10%
Low(50–70)7%
Very low(< 50)31%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ectodermal dysplasia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

wooly hair, autosomal recessive 3
0.69
Woolly hair
0.49
isolated familial wooly hair disorder
0.39
hypotrichosis 8
0.35
uncombable hair syndrome
0.11
oculocutaneous albinism type 6
0.11
ringed hair disease
0.11
uncombable hair syndrome 3
0.11
pili gemini
0.10
pili bifurcati
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Keratin, type I cytoskeletal 25

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (PubMed:26902920)