KRT3

Chr 12q13.13

keratin 3

Aliases:: CK3, K3
MANE:: ENST00000417996.2

OMIM: 148043 ↗NCBI: 3850 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

KRT3 · P12035

v62025-08-01

Predicted Aligned Error matrix for KRT3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

63.3/ 100

Low

628 residues

Confidence breakdown

Very high(≥ 90)32%
Confident(70–90)14%
Low(50–70)7%
Very low(< 50)48%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Corneal abnormalities
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Corneal dystrophy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

corneal dystrophy, Meesmann, 2
0.67
Meesmann corneal dystrophy
0.60
corneal dystrophy
0.34
corneal disorder
0.28
congenital hereditary endothelial dystrophy of cornea
0.11
Sjogren syndrome
0.08
hepatocellular carcinoma
0.06
esophageal adenocarcinoma
0.04
central nervous system cancer
0.03
keratoconus
0.03

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Keratin, type II cytoskeletal 3

Structural component of intermediate filaments in the corneal epithelium. Forms heteropolymers with the type I keratin KRT12, assembling into keratin intermediate filament networks that provide mechanical strength and structural integrity to the corneal epithelial layer