KRT6C

Chr 12q13.13

keratin 6C

MANE:: ENST00000252250.7

OMIM: 612315 ↗NCBI: 286887 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

KRT6C · P48668

v62025-08-01

Predicted Aligned Error matrix for KRT6C — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

66.8/ 100

Low

564 residues

Confidence breakdown

Very high(≥ 90)37%
Confident(70–90)15%
Low(50–70)7%
Very low(< 50)41%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ichthyosis and erythrokeratoderma
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Palmoplantar keratoderma and erythrokeratodermas
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Palmoplantar keratodermas
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Non-epidermolytic palmoplantar keratoderma
0.62
Autosomal dominant focal non-epidermolytic palmoplantar keratoderma with plantar blistering
0.55
palmoplantar keratoderma, nonepidermolytic, focal or diffuse
0.54
focal palmoplantar keratoderma
0.42
epidermolytic palmoplantar keratoderma, 1
0.38
hereditary palmoplantar keratoderma
0.37
Palmoplantar keratoderma
0.37
Nail dystrophy
0.37
hereditary disease
0.19
metabolic syndrome
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Keratin, type II cytoskeletal 6C

Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with the type I keratins, likely including KRT16 and KRT17, assembling keratin intermediate filament networks that contributes to the structural framework and mechanical resilience of stratified epithelia, particularly in palmoplantar epidermis