KRT8

Chr 12q13.13

keratin 8

Aliases:: CARD2, K8, CK8, CK-8, CYK8
MANE:: ENST00000692008.1

OMIM: 148060 ↗NCBI: 3856 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

KRT8 · P05787

v62025-08-01

Predicted Aligned Error matrix for KRT8 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.2/ 100

Confident

483 residues

Confidence breakdown

Very high(≥ 90)52%
Confident(70–90)14%
Low(50–70)9%
Very low(< 50)26%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Pancreatitis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Cirrhosis
0.60
cirrhosis, familial
0.40
neurodegenerative disease
0.37
exocrine pancreatic carcinoma
0.32
prostate carcinoma
0.31
Abnormality of the liver
0.30
sick sinus syndrome
0.28
familial sick sinus syndrome
0.28
Alzheimer disease
0.22
Parkinson disease
0.22

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Keratin, type II cytoskeletal 8

Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:26823019). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (PubMed:26823019). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (PubMed:16000376)