KRT81

Chr 12q13.13

keratin 81

Aliases:: Hb-1
MANE:: ENST00000327741.9

OMIM: 602153 ↗NCBI: 3887 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

KRT81 · Q14533

v62025-08-01

Predicted Aligned Error matrix for KRT81 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

71.9/ 100

Confident

505 residues

Confidence breakdown

Very high(≥ 90)48%
Confident(70–90)10%
Low(50–70)8%
Very low(< 50)34%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ectodermal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

monilethrix
0.67
monilethrix-2
0.42
monilethrix-1
0.41
neoplasm
0.09
lung adenocarcinoma
0.06
breast carcinoma
0.05
breast cancer
0.04
squamous cell carcinoma
0.03
ovarian carcinoma
0.03
ovarian cancer
0.03

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Keratin, type II cuticular Hb1

Structural component of intermediate filaments in the hair cortex (PubMed:10504448, PubMed:9402962). Forms obligate heterodimers with type I hair keratins, which assemble into keratin intermediate filaments that contribute to the structural integrity and mechanical strength of the hair shaft (PubMed:10504448, PubMed:9402962)