KRT86

Chr 12q13

keratin 86

Aliases:: MNX, Hb6
MANE:: ENST00000423955.7

OMIM: 601928 ↗NCBI: 3892 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

KRT86 · O43790

v62025-08-01

Predicted Aligned Error matrix for KRT86 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.5/ 100

Confident

486 residues

Confidence breakdown

Very high(≥ 90)51%
Confident(70–90)11%
Low(50–70)6%
Very low(< 50)33%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ectodermal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

monilethrix
0.77
monilethrix-1
0.46
monilethrix-2
0.42
Alzheimer disease
0.34
lysosomal storage disease
0.34
neurodegenerative disease
0.34
Parkinson disease
0.34
multiple sclerosis
0.34
hereditary disease
0.19
lamellar ichthyosis
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Keratin, type II cuticular Hb6

Structural component of intermediate filaments in the hair shaft (PubMed:15744029, PubMed:25557232). Forms obligate heterodimers with type I hair keratins, which assemble into keratin intermediate filaments that contribute to the structural integrity and mechanical strength of the hair shaft (PubMed:15744029, PubMed:25557232)