KRT9

Chr 17q21.2

keratin 9

Aliases:: EPPK, K9, CK-9
MANE:: ENST00000246662.9

OMIM: 607606 ↗NCBI: 3857 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KRT9 · P35527

v62025-08-01

Predicted Aligned Error matrix for KRT9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

62.1/ 100

Low

623 residues

Confidence breakdown

Very high(≥ 90)36%
Confident(70–90)9%
Low(50–70)5%
Very low(< 50)51%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ichthyosis and erythrokeratoderma
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Palmoplantar keratoderma and erythrokeratodermas
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Palmoplantar keratodermas
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

epidermolytic palmoplantar keratoderma, 1
0.83
palmoplantar keratoderma, epidermolytic
0.68
Localized epidermolytic hyperkeratosis
0.51
Palmoplantar keratoderma
0.44
hereditary disease
0.38
hereditary palmoplantar keratoderma
0.37
Familial prostate cancer
0.11
prostate cancer
0.11
erythrokeratodermia variabilis
0.09
Non-epidermolytic palmoplantar keratoderma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Keratin, type I cytoskeletal 9

Structural component of intermediate filaments in suprabasal keratinocytes of palmoplantar epidermis. Forms heteropolymers with a type II keratin, assembling into keratin intermediate filament networks that maintain the mechanical integrity of the palmoplantar epidermis