laminin subunit gamma 2
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Diagnostic Grade (Green)
Epidermolysis bullosa
BIALLELIC, autosomal or pseudoautosomalEpidermolysis bullosa and congenital skin fragility
BIALLELIC, autosomal or pseudoautosomalAmelogenesis imperfecta
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
BIALLELIC, autosomal or pseudoautosomalJunctional epidermolysis bullosa, Herlitz type
junctional epidermolysis bullosa Herlitz type
epidermolysis bullosa, junctional 3B, severe
epidermolysis bullosa, junctional 3A, intermediate
junctional epidermolysis bullosa
junctional epidermolysis bullosa, non-Herlitz type
Generalized junctional epidermolysis bullosa, non-Herlitz type
junctional epidermolysis bullosa inversa
localized junctional epidermolysis bullosa, non-Herlitz type
eye disorder
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Laminin subunit gamma-2
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells
LAMC2 · Q13753
Mean pLDDT
72.8/ 100
Confident
1,193 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
