LAMC3

Chr 9q34.12

laminin subunit gamma 3

Aliases:: DKFZp434E202
MANE:: ENST00000361069.9

OMIM: 604349 ↗NCBI: 10319 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

LAMC3 · Q9Y6N6

v62025-08-01

Predicted Aligned Error matrix for LAMC3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.8/ 100

Confident

1,575 residues

Confidence breakdown

Very high(≥ 90)15%
Confident(70–90)50%
Low(50–70)28%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Malformations of cortical development
BIALLELIC, autosomal or pseudoautosomal
Cerebral vascular malformations
Intellectual disability
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

occipital pachygyria and polymicrogyria
0.79
hereditary disease
0.51
eye disorder
0.43
androgenetic alopecia
0.42
bacterial infectious disease
0.37
Abnormal retinal morphology
0.37
macular holes
0.35
hydronephrosis
0.29
generalized anxiety disorder
0.28
male reproductive organ cancer
0.24

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Laminin subunit gamma-3

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components