LHB

Chr 19q13.33

luteinizing hormone subunit beta

Aliases:: LSH-B, CGB4, hLHB
MANE:: ENST00000649238.3

OMIM: 152780 ↗NCBI: 3972 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hypogonadotropic hypogonadism
BIALLELIC, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism (GMS)
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hypogonadotropic hypogonadism 23 with or without anosmia
0.68
Leydig cell hypoplasia due to LHB deficiency
0.64
hypogonadotropic hypogonadism
0.14
hepatocellular carcinoma
0.09
neoplasm
0.09
uterine disorder
0.09
Menkes disease
0.08
Kallmann syndrome
0.07
46,XX testicular disorder of sex development
0.07
46,XY complete gonadal dysgenesis
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Lutropin subunit beta

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids