LHCGR

Chr 2p16.3

luteinizing hormone/choriogonadotropin receptor

Aliases:: LHR, LCGR, LGR2, ULG5
MANE:: ENST00000294954.12

OMIM: 152790 ↗NCBI: 3973 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

LHCGR · P22888

v62025-08-01

Predicted Aligned Error matrix for LHCGR — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.1/ 100

Confident

699 residues

Confidence breakdown

Very high(≥ 90)49%
Confident(70–90)28%
Low(50–70)7%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Differences in sex development
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Leydig cell hypoplasia, type 1
0.78
familial male-limited precocious puberty
0.74
female infertility
0.56
peripheral precocious puberty
0.56
Infertility
0.53
infertility disorder
0.53
anovulation
0.49
Precocious puberty in males
0.49
primary ovarian failure
0.48
Abnormality of the skeletal system
0.45

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Lutropin-choriogonadotropic hormone receptor

Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099)

Curated MONDO disease pages that list LHCGR among their top associated genes.

polycystic ovary syndromeRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with LHCGR