LILRB1

Chr 19q13.42

leukocyte immunoglobulin like receptor B1

Aliases:: LIR-1, ILT2, MIR-7, CD85, LIR1
MANE:: ENST00000324602.12

OMIM: 604811 ↗NCBI: 10859 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

LILRB1 · Q8NHL6

v62025-08-01

Predicted Aligned Error matrix for LILRB1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.4/ 100

Confident

650 residues

Confidence breakdown

Very high(≥ 90)52%
Confident(70–90)11%
Low(50–70)6%
Very low(< 50)32%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

Epstein-Barr virus infection
0.21
response to stimulus
0.10
Miyoshi myopathy
0.10
neoplasm
0.10
gastric cancer
0.09
cancer
0.09
rheumatoid arthritis
0.09
systemic lupus erythematosus
0.09
acute myeloid leukemia
0.09
glioblastoma
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Leukocyte immunoglobulin-like receptor subfamily B member 1

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:19304799, PubMed:29262349). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251)