LIM2

Chr 19q13.41

lens intrinsic membrane protein 2

Aliases:: MP19, MP17
MANE:: ENST00000596399.2

OMIM: 154045 ↗NCBI: 3982 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

LIM2 · P55344

v62025-08-01

Predicted Aligned Error matrix for LIM2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.3/ 100

Very high

173 residues

Confidence breakdown

Very high(≥ 90)68%
Confident(70–90)27%
Low(50–70)5%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bilateral congenital or childhood onset cataracts
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

early-onset non-syndromic cataract
0.61
Total congenital cataract
0.40
cataract
0.38
neurodegenerative disease
0.37
total early-onset cataract
0.37
hereditary disease
0.19
lens disorder
0.12
Posterior polar cataract
0.12
early-onset zonular cataract
0.12
Partial congenital cataract
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Lens fiber membrane intrinsic protein

Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis