LINGO1

Chr 15q24.3

leucine rich repeat and Ig domain containing 1

Aliases:: FLJ14594, LERN1
MANE:: ENST00000355300.7

OMIM: 609791 ↗NCBI: 84894 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

LINGO1 · Q96FE5

v62025-08-01

Predicted Aligned Error matrix for LINGO1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.1/ 100

Confident

620 residues

Confidence breakdown

Very high(≥ 90)77%
Confident(70–90)5%
Low(50–70)3%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

intellectual disability, autosomal recessive 64
0.67
type 1 diabetes mellitus
0.37
major depressive disorder
0.34
stroke disorder
0.34
post-traumatic stress disorder
0.33
alcohol drinking
0.33
Abnormality of the skeletal system
0.32
mathematical ability
0.31
smoking initiation
0.31
essential tremor
0.30

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)