LLGL2

Chr 17q25.1

LLGL scribble cell polarity complex component 2

Aliases:: HGL, Hugl-2
MANE:: ENST00000392550.8

OMIM: 618483 ↗NCBI: 3993 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

LLGL2 · Q6P1M3

v62025-08-01

Predicted Aligned Error matrix for LLGL2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.9/ 100

Confident

1,020 residues

Confidence breakdown

Very high(≥ 90)75%
Confident(70–90)6%
Low(50–70)3%
Very low(< 50)15%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Inherited ovarian cancer (without breast cancer)
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

neurodegenerative disease
0.44
neoplasm
0.08
hepatocellular carcinoma
0.08
breast cancer
0.08
breast carcinoma
0.08
ovarian carcinoma
0.08
ovarian cancer
0.07
esophageal squamous cell carcinoma
0.07
benign prostatic hyperplasia
0.07
Hyperlipoproteinemia type 5
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

LLGL scribble cell polarity complex component 2

Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity