LPAR6

Chr 13q14.2

lysophosphatidic acid receptor 6

Aliases:: P2Y5
MANE:: ENST00000620633.5

OMIM: 609239 ↗NCBI: 10161 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

LPAR6 · P43657

v62025-08-01

Predicted Aligned Error matrix for LPAR6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.4/ 100

Confident

344 residues

Confidence breakdown

Very high(≥ 90)49%
Confident(70–90)37%
Low(50–70)13%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ectodermal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Non-syndromic hypotrichosis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hypotrichosis simplex
0.74
hypotrichosis 8
0.73
hypotrichosis 7
0.46
wooly hair, autosomal recessive 1, with or without hypotrichosis
0.45
isolated familial wooly hair disorder
0.37
Woolly hair
0.37
wooly hair, autosomal recessive 3
0.34
hereditary disease
0.19
retinoblastoma
0.12
hepatocellular carcinoma
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Lysophosphatidic acid receptor 6

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture