AlphaFold predicted structure
LRP12 · Q9Y561
Mean pLDDT
62.5/ 100
Low
859 residues
Confidence breakdown
- Very high(≥ 90)13%
- Confident(70–90)38%
- Low(50–70)14%
- Very low(< 50)36%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
LRP12
Chr 8q22.3LDL receptor related protein 12
- Aliases:
- ST7, FLJ12929
- MANE:
- ENST00000276654.10
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Hereditary neuropathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedHereditary neuropathy or pain disorder
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
oculopharyngodistal myopathy
0.47oculopharyngodistal myopathy 1
0.45amyotrophic lateral sclerosis 28
0.43hypertensive disorder
0.40amyotrophic lateral sclerosis
0.38type 2 diabetes mellitus
0.34alcohol drinking
0.33atrial fibrillation
0.32respiratory tract infectious disorder
0.29Abnormal abdomen morphology
0.25
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Low-density lipoprotein receptor-related protein 12
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor