LRP6

Chr 12p13.2

LDL receptor related protein 6

Aliases:: ADCAD2
MANE:: ENST00000261349.9

OMIM: 603507 ↗NCBI: 4040 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

LRP6 · O75581

v62025-08-01

Predicted Aligned Error matrix for LRP6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.2/ 100

Confident

1,613 residues

Confidence breakdown

Very high(≥ 90)51%
Confident(70–90)28%
Low(50–70)4%
Very low(< 50)17%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ectodermal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Osteogenesis imperfecta
Skeletal dysplasia

Disease associations (Open Targets)

tooth agenesis, selective, 7
0.70
coronary artery disease, autosomal dominant 2
0.70
tooth agenesis
0.64
Oligodontia
0.55
hereditary disease
0.49
orofacial cleft
0.40
autosomal dominant hypohidrotic ectodermal dysplasia
0.38
androgenetic alopecia
0.35
ectodermal dysplasia syndrome
0.34
Isolated polycystic liver disease
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Low-density lipoprotein receptor-related protein 6

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812, PubMed:34896607). Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in various processes including retinal angiogenesis and bone formation (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812, PubMed:34896607). The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin (PubMed:16513652). Required for posterior patterning of the epiblast during gastrulation (By similarity)