LRRC45

Chr 17q25.3

leucine rich repeat containing 45

Aliases:: MGC20806
MANE:: ENST00000306688.8

OMIM: 621312 ↗NCBI: 201255 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

LRRC45 · Q96CN5

v62025-08-01

Predicted Aligned Error matrix for LRRC45 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.4/ 100

Confident

670 residues

Confidence breakdown

Very high(≥ 90)43%
Confident(70–90)45%
Low(50–70)8%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Neurological ciliopathies
BIALLELIC, autosomal or pseudoautosomal
Ophthalmological ciliopathies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.28
ciliopathy
0.25
Abnormal brain morphology
0.25
neurodevelopmental disorder
0.25
neuroblastoma
0.17
lung carcinoma
0.03
lung cancer
0.03
urinary bladder carcinoma
0.02
urinary bladder cancer
0.02
Cone rod dystrophy
0.01

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Leucine-rich repeat-containing protein 45

Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion (PubMed:24035387). Is probably involved in the early stages of ciliogenesis (PubMed:30131441, PubMed:39638757). Plays a role in the organization of centriolar satellites, likely by regulating the accumulation of centriolar satellite proteins, such as PCM1 and SSX2IP, at the centrosome (PubMed:30131441)