LSM1

Chr 8p11.23

LSM1 homolog, mRNA degradation associated

Aliases:: CASM, YJL124C
MANE:: ENST00000311351.9

OMIM: 607281 ↗NCBI: 27257 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

LSM1 · O15116

v62025-08-01

Predicted Aligned Error matrix for LSM1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.7/ 100

Confident

133 residues

Confidence breakdown

Very high(≥ 90)76%
Confident(70–90)17%
Low(50–70)4%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

FICUS syndrome
0.50
Global developmental delay
0.26
schizophrenia
0.17
gout
0.16
risk-taking behaviour
0.13
Neurodevelopmental delay
0.12
Generalized hypotonia
0.12
Mitral stenosis
0.12
Inguinal hernia
0.12
Bicuspid aortic valve
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

U6 snRNA-associated Sm-like protein LSm1

Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity)