LSM11

Chr 5q33.3

LSM11, U7 small nuclear RNA associated

Aliases:: FLJ38273
MANE:: ENST00000286307.6

OMIM: 617910 ↗NCBI: 134353 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

LSM11 · P83369

v62025-08-01

Predicted Aligned Error matrix for LSM11 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

64.3/ 100

Low

360 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)27%
Low(50–70)17%
Very low(< 50)39%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.53
Aicardi-Goutieres syndrome 8
0.50
Aicardi-Goutieres syndrome
0.37
Aicardi-Goutières syndrome
0.37
dysthymic disorder
0.05
major depressive disorder
0.05
hepatocellular carcinoma
0.04
hypertensive disorder
0.03
Alzheimer disease
0.03
Increased blood pressure
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

U7 snRNA-associated Sm-like protein LSm11

Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:11574479, PubMed:16914750, PubMed:33230297). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:11574479, PubMed:16914750). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to the Sm-binding site of U7 snRNA (PubMed:11574479, PubMed:16914750)