LSM7

Chr 19p13.3

LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

Aliases:: YNL147W
MANE:: ENST00000252622.15

OMIM: 607287 ↗NCBI: 51690 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

LSM7 · Q9UK45

v62025-08-01

Predicted Aligned Error matrix for LSM7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.4/ 100

Confident

103 residues

Confidence breakdown

Very high(≥ 90)70%
Confident(70–90)19%
Low(50–70)8%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Ataxia and cerebellar anomalies - narrow panel
BIALLELIC, autosomal or pseudoautosomal
Childhood onset hereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
White matter disorders and cerebral calcification - narrow panel
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.53
leukodystrophy
0.40
LSM7-related leukodystrophy and cerebellar atrophy
0.33
Joubert syndrome 36
0.27
hepatocellular carcinoma
0.07
neoplasm
0.05
breast cancer
0.04
breast carcinoma
0.02
Cerebellar atrophy
0.02
cancer
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

U6 snRNA-associated Sm-like protein LSm7

Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166, PubMed:35047835). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320)