LSR

Chr 19q13.12

lipolysis stimulated lipoprotein receptor

Aliases:: LISCH7, ILDR3
MANE:: ENST00000605618.6

OMIM: 616582 ↗NCBI: 51599 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

LSR · Q86X29

v62025-08-01

Predicted Aligned Error matrix for LSR — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

57.4/ 100

Low

649 residues

Confidence breakdown

Very high(≥ 90)14%
Confident(70–90)16%
Low(50–70)17%
Very low(< 50)52%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Cholestasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.34
progressive familial intrahepatic cholestasis
0.27
progressive familial intrahepatic cholestasis type 1
0.27
Intellectual disability
0.19
Short stature
0.18
short stature due to GHSR deficiency
0.18
lysosomal storage disease
0.11
endometrial cancer
0.07
lung adenocarcinoma
0.07
neoplasm
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Lipolysis-stimulated lipoprotein receptor

Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity)