AlphaFold predicted structure
LYRM7 · Q5U5X0
Mean pLDDT
91.8/ 100
Very high
104 residues
Confidence breakdown
- Very high(≥ 90)75%
- Confident(70–90)21%
- Low(50–70)3%
- Very low(< 50)1%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
LYRM7
Chr 5q23.3-q31.1LYR motif containing 7
- Aliases:
- FLJ20796, MZM1L
- MANE:
- ENST00000379380.9
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Inherited white matter disorders
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorder with complex III deficiency
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomalWhite matter disorders and cerebral calcification - narrow panel
BIALLELIC, autosomal or pseudoautosomalPaediatric or syndromic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Isolated CoQ-cytochrome C reductase deficiency
0.79mitochondrial complex III deficiency
0.55mitochondrial disease
0.37inborn mitochondrial metabolism disorder
0.37mitochondrial complex III deficiency nuclear type 1
0.34Varicose veins
0.30asthma
0.29Abnormality of the skeletal system
0.29chronic rhinosinusitis
0.24diabetic ketoacidosis
0.21
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Complex III assembly factor LYRM7
Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane