LYZ

Chr 12q15

lysozyme

MANE:: ENST00000261267.7

OMIM: 153450 ↗NCBI: 4069 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

LYZ · P61626

v62025-08-01

Predicted Aligned Error matrix for LYZ — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

94.1/ 100

Very high

148 residues

Confidence breakdown

Very high(≥ 90)88%
Confident(70–90)2%
Low(50–70)9%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hereditary systemic amyloidosis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Periodic fever syndromes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

familial visceral amyloidosis
0.62
Familial renal amyloidosis
0.62
amyloidosis, hereditary systemic 5
0.55
Oral ulcer
0.48
AL amyloidosis
0.47
Renal amyloidosis
0.47
hypertensive disorder
0.46
ALys amyloidosis
0.37
Familial renal amyloidosis due to lysozyme variant
0.37
alcohol drinking
0.24

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Lysozyme C

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents