AlphaFold predicted structure
MAG · P20916
Mean pLDDT
80.8/ 100
Confident
626 residues
Confidence breakdown
- Very high(≥ 90)62%
- Confident(70–90)16%
- Low(50–70)4%
- Very low(< 50)18%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
MAG
Chr 19q13.1myelin associated glycoprotein
- Aliases:
- SIGLEC4A, SIGLEC-4A, S-MAG, SIGLEC4
- MANE:
- ENST00000392213.8
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Ataxia and cerebellar anomalies - narrow panel
BIALLELIC, autosomal or pseudoautosomalChildhood onset hereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomalHereditary neuropathy or pain disorder
BIALLELIC, autosomal or pseudoautosomalHereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalOptic neuropathy
BIALLELIC, autosomal or pseudoautosomalAdult onset hereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomalAdult onset neurodegenerative disorder
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Autosomal recessive spastic paraplegia type 75
0.79complex hereditary spastic paraplegia
0.37orofacial cleft 1
0.27hereditary disease
0.19diabetes mellitus
0.18hereditary spastic paraplegia
0.17chronic inflammatory demyelinating polyradiculoneuropathy
0.12neuropathy
0.11Stroke
0.10Parkinson disease
0.10
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Myelin-associated glycoprotein
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth (By similarity). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b (By similarity)