MAP3K14

Chr 17q21.31

mitogen-activated protein kinase kinase kinase 14

Aliases:: NIK, HSNIK, FTDCR1B, HS
MANE:: ENST00000344686.8

OMIM: 604655 ↗NCBI: 9020 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MAP3K14 · Q99558

v62025-08-01

Predicted Aligned Error matrix for MAP3K14 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

60.8/ 100

Low

947 residues

Confidence breakdown

Very high(≥ 90)30%
Confident(70–90)13%
Low(50–70)6%
Very low(< 50)51%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency 112
0.57
NIK deficiency
0.51
Abnormality of the skeletal system
0.32
autoimmune disorder of central nervous system
0.27
atopic eczema
0.21
multiple sclerosis
0.20
type 1 diabetes mellitus
0.18
asthma
0.18
preeclampsia
0.17
Abnormal erythrocyte morphology
0.16

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Mitogen-activated protein kinase kinase kinase 14

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway (PubMed:25406581, PubMed:29230214). Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response (PubMed:25406581). Could act in a receptor-selective manner