AlphaFold predicted structure
MAP3K3 · Q99759
Mean pLDDT
66.9/ 100
Low
626 residues
Confidence breakdown
- Very high(≥ 90)37%
- Confident(70–90)18%
- Low(50–70)4%
- Very low(< 50)41%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
MAP3K3
Chr 17q23.3mitogen-activated protein kinase kinase kinase 3
- Aliases:
- MAPKKK3
- MANE:
- ENST00000361733.8
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Mosaic skin disorders - deep sequencing
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
verrucous hemangioma
0.38neurodegenerative disease
0.37cerebral cavernous malformations 5
0.17Abnormality of the skeletal system
0.13neoplasm
0.09cerebral cavernous malformation
0.09lung carcinoma
0.08lung cancer
0.08esophageal squamous cell carcinoma
0.07posterior cortical atrophy
0.07
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Mitogen-activated protein kinase kinase kinase 3
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators