MAPT

Chr 17q21.31

microtubule associated protein tau

Aliases:: MTBT1, tau, PPND, FTDP-17, TAU
MANE:: ENST00000262410.10

OMIM: 157140 ↗NCBI: 4137 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MAPT · P10636

v62025-08-01

Predicted Aligned Error matrix for MAPT — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

49.2/ 100

Very low

758 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)8%
Low(50–70)27%
Very low(< 50)66%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Adult onset dystonia, chorea or related movement disorder
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Adult onset neurodegenerative disorder
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Early onset dementia (encompassing fronto-temporal dementia and prion disease)
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Parkinson Disease and Complex Parkinsonism
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

frontotemporal dementia
0.79
Pick disease
0.76
supranuclear palsy, progressive, 1
0.73
Progressive supranuclear palsy - parkinsonism
0.71
Atypical progressive supranuclear palsy
0.71
Classical progressive supranuclear palsy
0.70
progressive supranuclear palsy-parkinsonism syndrome
0.65
late-onset Parkinson disease
0.64
semantic dementia
0.64
progressive supranuclear palsy
0.61

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Microtubule-associated protein tau

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization