AlphaFold predicted structure
MAST3 · O60307
Mean pLDDT
57.1/ 100
Low
1,309 residues
Confidence breakdown
- Very high(≥ 90)21%
- Confident(70–90)18%
- Low(50–70)7%
- Very low(< 50)54%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
MAST3
Chr 19p13.11microtubule associated serine/threonine kinase 3
- Aliases:
- KIAA0561
- MANE:
- ENST00000687212.1
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEarly onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
developmental and epileptic encephalopathy 108
0.57hereditary disease
0.38pervasive developmental disorder
0.34Rare pervasive developmental disorder
0.34intelligence
0.26developmental and epileptic encephalopathy
0.21health study participation
0.20obesity disorder
0.20autism spectrum disorder
0.19attention deficit-hyperactivity disorder
0.19
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Microtubule-associated serine/threonine-protein kinase 3
Serine/threonine kinase that phosphorylates ARPP19 at 'Ser-62', resulting in protein phosphatase 2A (PP2A) inhibition by ARPP19