MBL2

Chr 10q21.1

mannose binding lectin 2

Aliases:: COLEC1, MBP-C, MBP1, MBP
MANE:: ENST00000674931.1

OMIM: 154545 ↗NCBI: 4153 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

MBL2 · P11226

v62025-08-01

Predicted Aligned Error matrix for MBL2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.6/ 100

Confident

248 residues

Confidence breakdown

Very high(≥ 90)55%
Confident(70–90)17%
Low(50–70)16%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Primary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

bone fracture
0.43
COVID-19
0.40
dengue disease
0.39
complement deficiency
0.37
pernicious anemia
0.32
placental abruption
0.32
ulna fracture
0.30
radius fracture
0.30
androgenetic alopecia
0.30
Abnormal nasolacrimal system morphology
0.25

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Mannose-binding protein C

Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:14515269, PubMed:22966085, PubMed:7634089, PubMed:9087411). Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:22966085, PubMed:2573758, PubMed:6643429, PubMed:8082295, PubMed:9087411). Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342). May bind DNA (PubMed:15145932)