MCAT

Chr 22q13.2

malonyl-CoA-acyl carrier protein transacylase

Aliases:: MT, MCT, fabD, FASN2C, NET62
MANE:: ENST00000290429.11

OMIM: 614479 ↗NCBI: 27349 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

MCAT · Q8IVS2

v62025-08-01

Predicted Aligned Error matrix for MCAT — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.1/ 100

Confident

390 residues

Confidence breakdown

Very high(≥ 90)79%
Confident(70–90)3%
Low(50–70)5%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Optic neuropathy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.53
optic atrophy 15
0.42
Autosomal recessive isolated optic atrophy
0.37
hereditary optic neuropathy
0.19
prostate carcinoma
0.18
Retinal dystrophy
0.17
Alzheimer disease
0.09
infectious otitis media
0.08
neoplasm
0.08
amyotrophic lateral sclerosis
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1) (PubMed:12882974, PubMed:19549604). This suggests the existence of the biosynthesis of fatty acids in mitochondria (PubMed:12882974). Also acts as a mitochondrial small ribosomal subunit (mt-SSU) assembly factor (PubMed:36482135)