AlphaFold predicted structure
MCIDAS · D6RGH6
Mean pLDDT
60.6/ 100
Low
385 residues
Confidence breakdown
- Very high(≥ 90)20%
- Confident(70–90)14%
- Low(50–70)20%
- Very low(< 50)47%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
MCIDAS
Chr 5q11.2multiciliate differentiation and DNA synthesis associated cell cycle protein
- Aliases:
- MCI, IDAS
- MANE:
- ENST00000513312.3
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomalPrimary ciliary disorders
BIALLELIC, autosomal or pseudoautosomalRespiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomalRare multisystem ciliopathy disorders
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
primary ciliary dyskinesia
0.79Hydrocephalus
0.38arachnoid cyst
0.37neurodegenerative disease
0.28hereditary disease
0.19autism
0.05citrullinemia type II
0.04X-linked adrenoleukodystrophy
0.0415q11q13 microduplication syndrome
0.04ciliopathy
0.03
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Multicilin
Transcription regulator specifically required for multiciliate cell differentiation (PubMed:25048963). Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211)
Diseases associated with MCIDAS
Curated MONDO disease pages that list MCIDAS among their top associated genes.