MCM4

Chr 8q11.21

minichromosome maintenance complex component 4

Aliases:: CDC54, hCdc21, P1-Cdc21, MGC33310
MANE:: ENST00000649973.1

OMIM: 602638 ↗NCBI: 4173 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

MCM4 · P33991

v62025-08-01

Predicted Aligned Error matrix for MCM4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.6/ 100

Confident

863 residues

Confidence breakdown

Very high(≥ 90)14%
Confident(70–90)57%
Low(50–70)10%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Congenital adrenal hypoplasia

Disease associations (Open Targets)

Immunodeficiency with natural-killer cell deficiency and adrenal insufficiency
0.71
primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency
0.65
Cytomegalic congenital adrenal hypoplasia
0.18
microcephaly
0.11
hepatocellular carcinoma
0.10
non-small cell lung carcinoma
0.10
cancer
0.09
breast cancer
0.09
breast carcinoma
0.08
melanoma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

DNA replication licensing factor MCM4

Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914)