MED16

Chr 19p13.3

mediator complex subunit 16

Aliases:: DRIP92, TRAP95
MANE:: ENST00000325464.6

OMIM: 604062 ↗NCBI: 10025 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

MED16 · Q9Y2X0

v62025-08-01

Predicted Aligned Error matrix for MED16 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.0/ 100

Confident

877 residues

Confidence breakdown

Very high(≥ 90)59%
Confident(70–90)26%
Low(50–70)6%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Clefting
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Guillouet-Gordon syndrome
0.64
neurodegenerative disease
0.49
syndromic intellectual disability
0.42
retinitis pigmentosa
0.30
melanoma
0.15
oral cavity carcinoma
0.15
Genu valgum
0.13
Genu varum
0.13
biliary tract disorder
0.10
breast cancer
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Mediator of RNA polymerase II transcription subunit 16

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors